Nanomechanical Characterization of Amyloid Fibrils Using Single-Molecule Experiments and Computational Simulations

Figure 7

Nanomechanical properties of -microglobulin fibrils made of one to five filaments, respectively. (a) The length-dependent effective bending rigidity of -microglobulin fibrils composed of one to five filaments, respectively. (b) The intrinsic bending rigidity of -microglobulin fibrils made of two to five filaments, respectively, is shown as a function of the number of filaments comprising the fibrils. The dots indicate the results of ENM simulations, while solid line presents the theoretical prediction from continuum helical fibril model. Figures are adopted with permission from [34].

(a)

(b)