Gold Nanoparticles Synthesized with a Polyphenols-Rich Extract from Cornelian Cherry (Cornus mas) Fruits: Effects on Human Skin Cells

Figure 5

TEM images of keratinocytes from two lines: normal cells, HaCaT (a–c), and malignant cells, A431 (d–f). (a) Control HaCaT cell with normal ultrastructure. (b) Cytoplasmic localization of gold nanoparticles (GNPs) in small vesicles (v). (c) Cytoplasmic localization of GNPs as clusters in cytosol. (d) Epidermoid carcinoma cell with modified ultrastructure. (e) Cytoplasmic localization of GNPs in the proximity of plasma membrane. (f) Cytoplasmic localization of GNPs as clusters deeper inside the cell. n: nucleus; nu: nucleolus; m: mitochondria; er: endoplasmic reticulum; g: glycogen granules; l: lipid droplets; ne: nuclear envelope.