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Journal of Nanomaterials
Volume 2016, Article ID 7201204, 16 pages
http://dx.doi.org/10.1155/2016/7201204
Research Article

Penetration and Silencing Activity of VEGF Dicer Substrate siRNA Vectorized by Chitosan Nanoparticles in Monolayer Culture and a Solid Tumor Model In Vitro for Potential Application in Tumor Therapy

1Centre for Drug Delivery Research, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
2Program of Biomedical Science, School of Diagnostic and Applied Health Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia

Received 5 April 2016; Accepted 25 July 2016

Academic Editor: Hua Zou

Copyright © 2016 Maria Abdul Ghafoor Raja et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Table S1 presents particle size, zeta potential and PDI of unloaded CS-TPP nanoparticles prepared at different CS concentration ranging from 0.1% to 0.4% w/v. The mean particle size of CS-TPP nanoparticles was increased significantly by increasing the CS concentration. PDI values of these nanoparticles were from 0.3 to 0.6 and within the acceptable range. The surface charge of CS-TPP nanoparticles ranged from +30.1 ± 1.0 to +59.7 ± 0.5 mV by varying CS concentrations from 0.1% to 0.4% w/v. This was expected because higher CS concentrations have more unneutralised NH3+groups of CS, thus resulting in higher zeta potential.

  1. Supplementary Material