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Journal of Nanomaterials
Volume 2016, Article ID 7350516, 10 pages
http://dx.doi.org/10.1155/2016/7350516
Research Article

Poly-γ-Glutamic Acid Nanoparticles Based Visible Light-Curable Hydrogel for Biomedical Application

1Department of Biomaterials and Prosthetic Dentistry, University of Debrecen, Nagyerdei krt. 98, Debrecen 4032, Hungary
2Department of Periodontology, University of Debrecen, Nagyerdei krt. 98, Debrecen 4032, Hungary
3Department of Solid State Physics, University of Debrecen, Nagyerdei krt. 98, Debrecen 4032, Hungary
4Department of Physiology, University of Debrecen, Nagyerdei krt. 98, Debrecen 4032, Hungary
5Department of Applied Mathematics and Probability Theory, University of Debrecen, Nagyerdei krt. 98, Debrecen 4032, Hungary

Received 18 January 2016; Accepted 12 May 2016

Academic Editor: Ester Vazquez

Copyright © 2016 József Bakó et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Nanoparticles and hydrogels have gained notable attention as promising potential for fabrication of scaffolds and delivering materials. Visible light-curable systems can allow for the possibility of in situ fabrication and have the advantage of optimal applicability. In this study nanogel was created from methacrylated poly-gamma-glutamic acid nanoparticles by visible (dental blue) light photopolymerization. The average size of the particles was 80 nm by DLS, and the NMR spectra showed that the methacrylation rate was 10%. Polymerization time was 3 minutes, and a stable nanogel with a swelling rate of 110% was formed. The mechanical parameters of the prepared structure (compression stress 0.73 MPa, and Young’s modulus 0.93 MPa) can be as strong as necessary in a real situation, for example, in the mouth. A retaining effect of the nanogel was found for ampicillin, and the biocompatibility of this system was tested by Alamar Blue proliferation assay, while the cell morphology was examined by fluorescence and laser scanning confocal microscopy. In conclusion, the nanogel can be used for drug delivery, or it can be suitable for a control factor in different systems.