Preparation and Characterisation of Nobiletin-Loaded Nanostructured Lipid Carriers

Table 1

Variables with respective coded levels of the Box–Behnken design for the preparation and optimization of NOB-NLC.

Variables
Independent variables	Levels
	Low; (−1)	Medium; (0)	High; (+1)
: emulsifier-to-lipid ratio	1	1.75	2.5
: lecithin-to-Poloxamer 188 ratio	0.5	1.25	2
: liquid lipid-to-solid liquid ratio	0.33	1	1.67
Dependent variables	Constraints
: mean particle size (nm)	Minimum
: encapsulation efficiency (%)	Maximum