Preparation and Characterization of a Tumor-Targeting Dual-Image System Based on Iron Oxide Nanoparticles Functionalized with Folic Acid and Rhodamine

Figure 6

(a) Effect of folate-rhodamine-conjugated nanoparticles on the HeLa cells viability. Cells incubated with different nanoparticle concentrations for 24 h at 37°C followed by crystal violet staining. No significant reduction () in cellular viability was observed, the survival rate being higher than 80%, even at the highest nanoparticle concentration. (b) Photomicrographs of cellular uptake test in HeLa cells at two different concentrations. The black arrows show the internalization of the system, which is visible even at low concentrations (0.065 mg mL⁻¹).

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