Interaction of Solid Lipid Nanoparticles and Specific Proteins of the Corona Studied by Surface Plasmon Resonance

Figure 6

Sensorgrams showing the SPR signal resulting from the injection of the solid lipid nanoparticles (a) P188, (b) P188+, (c) PVA, (d) CL, and (e) CM over control surface without immobilized protein (sensor surface: Au-MUA). Each cycle included a ten-minute injection of the SLN solution followed by a washing step with running buffer (PBS pH 7.4). SPR response arising from the interaction of chitosan-coated SLN and the control surface corresponds to the stabilization of the signal after the end of the SLN injection (at around 1000 s).

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