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Journal of Nanomaterials
Volume 2017, Article ID 6796412, 7 pages
https://doi.org/10.1155/2017/6796412
Research Article

Synthesis, Characterization, and Drug Delivery from pH- and Thermoresponsive Poly(N-Isopropylacrylamide)/Chitosan Core/Shell Nanocomposites Made by Semicontinuous Heterophase Polymerization

1Departamento de Ingenieria Mecanica Electrica, Universidad de Guadalajara, Boul. M. García-Barragán #1451, 44430 Guadalajara, JAL, Mexico
2Ingeniería Química, Universidad de Guadalajara, Boul. M. García-Barragán #1451, 44430 Guadalajara, JAL, Mexico
3Física, Universidad de Guadalajara, Boul. M. García-Barragán #1451, 44430 Guadalajara, JAL, Mexico
4Centro de Investigación en Química Aplicada, Av. Ing. E. Reyna #140, 25294 Saltillo, COAH, Mexico

Correspondence should be addressed to Jorge E. Puig; xm.gdu.liam@ejgiup

Received 31 August 2016; Revised 16 December 2016; Accepted 19 December 2016; Published 24 January 2017

Academic Editor: Xuping Sun

Copyright © 2017 Abraham G. Alvarado et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Temperature- and pH-responsive core/shell nanoparticles were prepared by semicontinuous heterophase polymerization of N-isopropylacrylamide (NIPA) in the presence of chitosan micelles for drug delivery purposes. Micelles of chitosan, formed in an acetic acid aqueous solution at 70°C containing potassium persulfate, were fed with N-isopropylacrylamide (NIPA) at a controlled rate, to produce PNIPA/chitosan core/shell nanoparticles of about 350 nm. Then, the crosslinking agent, glutaraldehyde, was added to crosslink the nanoparticles. These nanocomposites were temperature- and pH-responsive, which make them suitable as controlled drug releasing agents. The nanoparticles exhibit thermoreversibility to heating-and-cooling cycles and show different responses depending on the releasing medium’s pH. Drug delivery tests were performed, employing as a model drug, doxycycline hyclate.