Star Polymer-Drug Conjugates with pH-Controlled Drug Release and Carrier Degradation

Table 1

Physicochemical characteristics of linear polymer precursors and drug conjugate P5.

Polymer			Đ		Side chain groups
P1	25 100	16 700	1.5	1.4 (–TT)	–NHNH-Boc	—
P2	29 100	17 100	1.7	1.3 (–NH2)	–NHNH-Boc	—
P3	23 300	21 200	1.1	0.9 (–NH2)	–NHNH-Boc	—
P4	25 000	13 900	1.8	—	–NHNH2	—
P5	27 000	14 200	1.9	—	—	9.8

Molecular weight was determined by SEC using RI and MALS detection.
Polymer functionality of end groups (ratio of to calculated from the content of end groups determined as described in Section 2.5).
The DOX content was determined spectrophotometrically.