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Journal of Nanomaterials
Volume 2018, Article ID 1627879, 11 pages
https://doi.org/10.1155/2018/1627879
Research Article

Preparation and Evaluation of Smart Nanocarrier Systems for Drug Delivery Using Magnetic Nanoparticle and Avidin-Iminobiotin System

1National Engineering Laboratory for Rice and Byproduct Processing, Central South University of Forestry and Technology, Changsha, Hunan 410004, China
2National R&D Center for Egg Processing, Huazhong Agricultural University, Wuhan, Hubei 430070, China
3Department of Pathology, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK

Correspondence should be addressed to Tao Yang; moc.361@708oatgnay and Meihu Ma; moc.361@nhuhiemam

Received 30 March 2018; Accepted 27 May 2018; Published 28 August 2018

Academic Editor: Vidyadhar Singh

Copyright © 2018 Shuguo Sun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Therapeutic efficacy and the regulation of drug release can be improved by using selective targeting drug delivery systems. In this paper, we have demonstrated avidin-immobilized magnetic nanoparticles (AMNPs) as a novel targeted drug delivery system to deliver iminobiotinylated daunomycin (IDAU). TEM, XRD, VSM, and FTIR were employed for the physicochemical characterization of the drug-loaded MNPs. The binding of IDAU had little effect on sizes of AMNPs (~35 nm), but the stability and dispersibility of the nanoparticles were improved. The study also found that the loading capacity and efficiency of nanoparticles were mainly dependent on affinity interaction between IDAU and AMNPs. The optimal loading capacity and efficiency of MNPs for IDAU were 0.408 ± 0.012 mg/g and 94.18 ± 2.64% according to the reversed-phase high-performance liquid chromatography (RP-HPLC) data, respectively. Under the conditions of pH 6.8 and 1 mmol/L of biotin, the drug-loaded MNPs released rapidly at beginning and then maintained at a certain controllable release level. The effect of IDAU on DLKP proliferation was tested, and the results showed that IC50 was (1.60 ± 0.05) × 10−3 mg/mL. Our findings indicated that AMNPs hold tremendous potential as an effective drug delivery system.