Journal of Nanomaterials / 2018 / Article / Tab 2

Research Article

Porous Maltodextrin-Based Nanoparticles: A Safe Delivery System for Nasal Vaccines

Table 2

In vivo tolerability of the NPL. The mean weight variation (%) of the rats from the control (0) or the NPL-treated groups (2, 4, and 8 mg/kg/day (×2)) between nasal administration and sacrifice is reported. The expected immediate adverse effects, including sneezing, nose bleeding, runny nose, and watery eyes, were observed and recorded for 15 minutes after nasal administration. The anxiety- and pain-related behaviors and endpoints including aggressiveness, lack of movement, hunched posture, piloerection, ear position, eye tightening, or grooming were observed throughout the in vivo genotoxicity assessment. Finally, the percentage of mortality was also recorded.

NPL ((mg/kg/day) ×2)0248

Mean weight variation (%) (% min : % max)+2.20 (0 : 4.12)+2.68 (0.92 : 5.41)+2.02 (0 : 4.71)+2.36 (−1.95 : 6.19)
Nose bleedingNoNoNoNo
Runny noseNoNoNoNo
Watery eyesNoNoNoNo
Anxious behaviorNoNoNoNo
Death (%)0000

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