Nanocrystalline Hydroxyapatite-Based Scaffold Adsorbs and Gives Sustained Release of Osteoinductive Growth Factor and Facilitates Bone Regeneration in Mice Ectopic Model

Figure 3

Representative μ-CT images of (a) NHA, (b) L-BMP2-NHA, (c) M-BMP2-NHA, and (d) H-BMP2-NHA implanted subcutaneously in mice at week 4. Quantitative analysis of newly formed bone and trabecular parameters: (e) bone volume, (f) Tb.N, (g) Tb.Th, and (h) Tb.Sp. Data are presented as the mean ± SD, . Significant effect of the treatment: compared to control, and , compared to L-BMP, and , and compared to M-BMP, . L: low dose, M: medium dose, H: high dose.

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