|
| Clinical products | Formulation | Indication | Company | Year |
|
| Polymer-based nanoparticles |
| Renagel | Poly(allylamine hydrochloride) | Chronic kidney disease | Sanofi | 2000 |
| Eligard | Leuprolide acetate and polymer PLGA (poly (DL-lactide-co-glycolide)) | Prostate cancer | Tolmar | 2002 |
| Estrasorb | Micellar estradiol | Menopausal therapy | Novavax | 2003 |
| Cimzia/certolizumab pegol | PEGylated antibody fragment (certolizumab) | Crohn’s disease
Rheumatoid/psoriatic arthritis
Ankylosing spondylitis | UCB | 2008-2013 |
| Genexol-PM | mPEG-PLA micelle loaded with paclitaxel | Metastatic breast cancer | Samyang Corporation | 2007
South Korea |
| Adynovate | Polymer-protein conjugate (PEGylated factor VIII) | Hemophilia | Baxalta | 2015 |
|
| Lipid-based nanoparticles |
| Doxil/Caelyx | Liposomal doxorubicin | Ovarian, breast cancer, Kaposi’s sarcoma, and multiple myeloma | Janssen | 1995-2008 |
| DaunoXome | Liposomal daunorubicin | AIDS-related Kaposi’s sarcoma | Galen | 1996 |
| Myocet | Liposomal doxorubicin | Combination therapy with cyclophosphamide in metastatic breast cancer | Elan Pharmaceuticals | 2000 |
| Marqibo | Liposomal vincristine | Acute lymphoblastic leukemia | Talon Therapeutics Inc. | 2012 |
| AmBisome | Liposomal amphotericin B | Fungal/protozoal infections | Gilead Sciences | |
| Visudyne | Liposomal verteporfin | Choroidal neovascularisation, macular degeneration, wet age-related, myopia, and ocular histoplasmosis | Bausch and Lomb | 2000 |
| Onivyde | Liposomal irinotecan | Pancreatic cancer | Merrimack | 2015 |
|
| Inorganic and metallic nanoparticles |
| INFed | Iron dextran (low MW) | Iron deficiency in chronic kidney disease (CKD) | Sanofi Aventis | 1957 |
| Feridex/Endorem | SPION coated with dextran | Imaging agent | AMAG Pharmaceuticals | 1996-2008 |
| Venofer | Iron sucrose | Iron deficiency in chronic kidney disease (CKD) | Luitpold Pharmaceuticals | 2000 |
| GastroMARK; umirem | SPION coated with silicone | Imaging agent | AMAG Pharmaceuticals | 2001-2009 |
| NanoTherm | Iron oxide | Glioblastoma | MagForce | 2010 |
|
