Review Article

Recent Advances in the Synthesis, Properties, and Biological Applications of Platinum Nanoclusters

Figure 11

(a) Schematic route of fabricating caged Pt NCs (CPN) and the endocytosis pathway of CPN after conjugated with a tumour-penetrating peptide and PEG corona to form double-caged Pt NCs (DCPN). (b) Relative tumour volume and photographs of tumour size at the end point; the apoptotic cell death was detected by TUNEL assay after treated by CPN, and the scale bar is 20 μm. (c) Tumour target imaging, relative tumour volume, and body weight of mice after IT and IV injection by DCPN (reprinted major modification with permission from [201], Copyright 2013, Wiley).
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