Biological Characteristics and Carrier Functions of Pegylated Manganese Zinc Ferrite Nanoparticles

Figure 4

MRI study of PEG-MZF-NPs in vitro. (a). MRI of magnetic PEG-MZF-NP with different concentrations in vitro: (A) a normal saline group; (B) 0.04 μg/mL PEG-MZF-NP group; (C) 0.08 μg/mL PEG-MZF-NP group; (D) 0.16 μg/mL PEG-MZF-NP group; (E) 0.32 μg/mL PEG-MZF-NP group; (F) 0.64 μg/mL PEG-MZF-NP group; (G) 1.28 μg/mL PEG-MZF-NP group. PEG-MZF-NPs with different concentrations were scanned for MRI T2W1 sequence. It can be observed from the T2W1 image that with an increase in material concentration, the T2W1 signal significantly decreased. (b) T2 transverse relaxation time of PEG-MZF-NPs at different concentrations (r2). T2 values of PEG-MZF-NPs at different concentrations were measured, and relaxation rate r2 of materials was 6.06 μg·mL^-1 s^-1. These findings indicate a good potential for the MRI contrast agent.

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