Biological Characteristics and Carrier Functions of Pegylated Manganese Zinc Ferrite Nanoparticles

Table 1

MTT assay results after intervening L929 cells with PEG-MZF-NPs (, ).

Group	Absorbent biological material (OD value)	RGR (%)	Toxicity grade
Negative control group (MEM culture solution)		100	0
40 μg/mL group			1
60 μg/mL group			1
80 μg/mL group			1
Positive control group (acrylamide solution)			5

MTT assay was employed to detect the toxicity of magnetic NPs at different concentrations. After PEG-MZF-NPs were cocultured with L929 cells, the cell proliferation rates of negative control group were all 100% or so, and the cytotoxicity was grade 0, suggesting no cytotoxicity. The magnetic NP group with concentrations ranging from 40 g/mL to 80 g/mL had grade 1 cytotoxicity. In comparison, the cell proliferation rate in the positive control group was 39% and the cytotoxicity was grade 5.