Cavitation-Enhanced Delivery of the Nanomaterial Graphene Oxide-Doxorubicin to Hepatic Tumors in Nude Mice Using 20 kHz Low-Frequency Ultrasound and Microbubbles

Table 1

TEM of the vasculation in tumor tissues of nude mice in the four groups.

	Integrity of vascular endothelial cells	Vascular wall rupture	Extravascular erythrocyte	Black particles	Apoptosis of tumor cells
Control	Yes	No	No	No	Few
USMB	No	Yes	Yes	No	Some
GO-DOX	Yes	No	No	Yes	Some
USMB+GO-DOX	No	Yes	Yes	Yes	More