Journal of Nanomaterials / 2020 / Article / Fig 1

Research Article

The Synthesis of Glutamine-Functionalized Block Polymer and Its Application in Triple-Negative Breast Cancer Treatment

Figure 1

Expression of SLC1A5 in different subtypes of human breast cancer. (a) Kaplan-Meier analysis of overall survival of SLC1A5 in breast cancer. (b) The mRNA expression data of SLC1A5 downloaded from TCGA database in 113 normal human breast tissue samples and 5 subtypes of breast cancer with 449 luminal A, 181 luminal B, 69 HER2 positive, and 166 TNBC basal-like tissue samples and 33 TNBC normal-like tissue samples based on PAM50 intrinsic breast cancer subtypes; , , and . (c) Relative mRNA expression of SLC1A5 in the luminal A (MCF-7), luminal B (ZR-75-1), HER2 positive (SKBR3), and highly aggressive TNBC (MDA-MB-231, BT549) cell lines. Error bars represent the of at least three independent experiments; , , and . (d, e) Protein expression of SLC1A5 in the luminal A (MCF-7), luminal B (ZR-75-1), HER2 positive (SKBR3), and highly aggressive TNBC (MDA-MB-231, BT549) cell lines. Error bars represent the of at least three independent experiments; , , and , .
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