Novel Nano-Based Drug Delivery Systems Targeting Hepatic Stellate Cells in the Fibrotic Liver

Figure 2

Targeted drug delivery for activated HSC (HSCs) in the fibrotic liver. miRNA: microRNA; siRNA: RNA silencing; PNP: polymeric nanoparticles (NPs); VA: vitamin A; GA-CACNP: gallic acid- (GA-) zein/phospholipid composite NPs coupled with VA; RCP NPs: retinol-conjugated polyethyleneimine nanoparticles; CRM: collagenase I and retinol codecorated polymeric micelle based on poly-(lactic-co-glycolic)-b-poly(ethylene glycol)-maleimide; NO: nitric oxide; LSECs: liver sinusoidal endothelial cells; TD: targeted delivery; ECM: extracellular matrix; PDGF: platelet-derived growth factors; TGF-β: transforming growth factor-beta.