Mechanism, Clinical Significance, and Treatment Strategy of Warburg Effect in Hepatocellular Carcinoma

Table 2

The effects and targets of noncoding RNA on glucose metabolism of HCC cells.

Metabolism type	Target	Effects	Noncoding RNAs
Glucose uptake	GLUT1	Up	LINC01638 lncRNA [34]; lncRNA HOTAIR [35]; miR-181a-5p [36]; MiR-505 [37]
		Down	lncRNA SLC2A1-AS1 [38]; miR-342-3p [39]; miR-455-5p [40]; miR-328-3p [41]
Aerobic glycolysis	6-Phosphofructokinase-1	Up
		Down
	Hexokinase	Up	miR-181a-5p [36]
	Pyruvate kinase	Up	miR-4417 [43]; circMAT2B [44]
		Down	LncRNA WPDC2p [45]; miR-199a [46]; miR-491-5p [47]; miR-122 [48]
	LDH	Up	miR-181a-5p [36]
		Down
Tricarboxylic acid cycle and oxidative phosphorylation	Pyruvate dehydrogenase complex	Up
		Down
	Isocitrate dehydrogenase, IDH	Up
		Down
	α-Ketoglutarte dehydrogenase complex	Up
		Down
	Complex I-IV	Up	lncRNA MALAT1 [49]
	ATP synthase	Down
Pentose phosphate pathway	Glucose-6-phosphate dehydrogenase,G6PD	Up
		Down
Glutamine metabolism	ASCT2	Up
		Down
	Glutaminase	Up