|
| No. | Gene symbol | Full name | Function |
|
| 1 | EGF | Epidermal growth factor | EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. |
| 2 | IGF1 | Insulin like growth factor 1 | The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. |
| 3 | HGF | Hepatocyte growth factor | Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. |
| 4 | BMP4 | Bone morphogenetic protein 4 | Induces cartilage and bone formation. Also acts in mesoderm induction, tooth development, limb formation, and fracture repair. |
| 5 | CXCR4 | C-X-C motif chemokine receptor 4 | Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. |
| 6 | CTGF | IGF-binding protein 8 | Major connective tissue mitoattractant secreted by vascular endothelial cells. |
| 7 | THBS1 | Thrombospondin-1 | Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. |
| 8 | TGFB2 | Transforming growth factor beta-2 proprotein | Associates noncovalently with TGF-beta-2 and regulates its activation via interaction with “milieu molecules.” |
| 9 | JAK2 | Janus kinase 2 | Nonreceptor tyrosine kinase involved in various processes such as cell growth, development, differentiation, or histone modifications. |
| 10 | TGFB3 | Transforming growth factor beta 3 | Precursor of the latency-associated peptide (LAP) and transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. |
|
