MDR1 Genotypes and Haplotypes Are Closely Associated with Postoperative Fentanyl Consumption in Patients Undergoing Radical Gastrectomy

Table 5

Postoperative fentanyl consumption in different MDR1 haplotypes at the first 24 hours and 48 hours postoperatively.

Haplotypes	Frequency (%)	Fentanyl dose for 24 hours (μg/kg)	value	Fentanyl dose for 48 hours (μg/kg)	value
TTT	32.2	10.0 (7.4-15.0)	0.247	21.7 (17.2-26.2)	0.017^c
CGC	23.3	8.3 (6.7-10.0)		16.7 (14.0-20.1)
CAC	17.8	7.8 (6.8-11.9)		17.1 (13.8-23.6)
TGC	17.4	10.1 (7.5-13.7)		19.8 (15.1-25.5)
Other	9.3	8.7 (7.2-11.9)		19.4 (14.6-21.3)

^cThe haplotype TTT required more fentanyl than the CGC haplotype at 48 hours postoperatively.