Cucurbitacin B as a Chinese Medicine Monomer Inhibits Cell Proliferation, Invasion, and Migration in Nasopharyngeal Carcinoma

Figure 6

Bioinformatics analysis uncovers MAPK as the central target of CuB. (a) Venn diagram of NPC therapeutic targets in the GeneCards database and CuB therapeutic targets in the PharmMapper database. (b, c) PPI analysis showing that MAPK1 had the strongest interaction with the other proteins. (d) MCC calculation concluded that MAPK1 has the highest score and is the core gene of the common target genes. (e) GO enrichment analysis of the top 5 functional sets of BF, CC, and MF. (f) The functional set in which MAPK1 was involved as the core. (g) The KEGG analysis of the screened common target genes (top 15 pathway). (h) Genes enriched in the MAPK pathway.

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