Research Article
Optimization of Formulation and Operating Parameters for Ginkgo biloba Extract Nanosuspension by Wet Ball Milling Using a Box–Behnken Design
Table 2
Particle size and dispersion coefficient (PDI) of GBE nanosuspension.
| Run | GBE concentration (g/L) | Milling speed (m/s) | Milling time (h) | SDS concentration (g/L) | Particle size (nm) | PDI |
| 1 | 3.3 | 6 | 1 | 0.5 | 203.4 | 0.505 | 2 | 13.2 | 6 | 1 | 0.5 | 197 | 1.215 | 3 | 3.3 | 10 | 1 | 0.5 | 178.6 | 0.565 | 4 | 13.2 | 10 | 1 | 0.5 | 365.6 | 0.386 | 5 | 6.6 | 8 | 0.5 | 0.1 | 568.1 | 1.055 | 6 | 6.6 | 8 | 2 | 0.1 | 512.8 | 0.302 | 7 | 6.6 | 8 | 0.5 | 1 | 213.9 | 0.561 | 8 | 6.6 | 8 | 2 | 1 | 181.5 | 0.441 | 9 | 3.3 | 8 | 1 | 0.1 | 198.5 | 0.286 | 10 | 13.2 | 8 | 1 | 0.1 | 664.3 | 0.425 | 11 | 3.3 | 8 | 1 | 1 | 205.9 | 0.669 | 12 | 13.2 | 8 | 2 | 1 | 173.1 | 0.366 | 13 | 6.6 | 6 | 0.5 | 0.5 | 240.4 | 0.635 | 14 | 6.6 | 10 | 0.5 | 0.5 | 223.8 | 0.518 | 15 | 6.6 | 6 | 2 | 0.5 | 185 | 0.527 | 16 | 6.6 | 10 | 2 | 0.5 | 191.8 | 0.748 | 17 | 3.3 | 8 | 0.5 | 0.5 | 200.9 | 0.481 | 18 | 13.2 | 8 | 0.5 | 0.5 | 209.3 | 0.378 | 19 | 3.3 | 8 | 2 | 0.5 | 185 | 0.553 | 20 | 13.2 | 8 | 2 | 0.5 | 177.3 | 0.302 | 21 | 6.6 | 6 | 1 | 0.1 | 525.3 | 1.125 | 22 | 6.6 | 10 | 1 | 0.1 | 649.8 | 0.216 | 23 | 6.6 | 6 | 1 | 1 | 201.9 | 0.594 | 24 | 6.6 | 10 | 1 | 1 | 195.9 | 0.527 | 25 | 6.6 | 8 | 1 | 0.5 | 197 | 0.473 | 26 | 6.6 | 8 | 1 | 0.5 | 203.8 | 0.598 | 27 | 6.6 | 8 | 1 | 0.5 | 212 | 0.585 | 28 | 6.6 | 8 | 1 | 0.5 | 203.8 | 0.408 | 29 | 6.6 | 8 | 1 | 0.5 | 191.7 | 0.449 |
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