Optimization of Formulation and Operating Parameters for Ginkgo biloba Extract Nanosuspension by Wet Ball Milling Using a Box–Behnken Design

Table 3

Summary of the analysis of variance (ANOVA) result for the quadratic model.

Run	Sum of square		Mean square	value	value
Model	597267.40	14	42661.96	12.81	<0.0001
	31447.04	1	31447.04	9.44	0.0083
	5313.02	1	5313.02	1.60	0.2271
	4144.08	1	4144.08	1.24	0.2834
	315770.96	1	315770.96	94.84	<0.0001
	9350.89	1	9350.89	2.81	0.1160
	64.80	1	64.80	0.019	0.8910
	62150.49	1	62150.49	18.67	0.0007
	136.89	1	136.89	0.041	0.8422
	4257.56	1	4257.56	1.28	0.2771
	131.10	1	131.10	0.039	0.8456
	1733.28	1	1733.28	0.52	0.4825
	7324.44	1	7324.44	2.20	0.1602
	0.002	1	0.002	4.88410^-7	0.9995
	146268.83	1	146268.83	43.93	<0.0001
Residual	46614.41	14	3329.60
Lack of fit	46377.42	10	4637.74	78.28	0.0004
Pure error	236.99	4	59.25
Col total	643881.81	28
Std. Dev.	57.70				0.9276
Mean	270.94		Adj-		0.8552
C. V. (%)	21.30		Pred-		0.5845
Press	267504.25		Adequate precision		13.825