Review Article

The Magnetic Nanomaterial Biofunctions in Cancer Diagnosis and Therapy

Table 1

Commonly used surface modification materials for magnetic nanoparticles.

MaterialPropertiesApplication

High molecular polymerDextran [70]Good biocompatibility and biodegradabilityStabilize the colloidal solution and increase the time of nanomaterial circulation in the blood
Polyethylene glycol (PEG) [71]With good hydrophilicity, it does not cause an immune response and antigen-antibody reactionReduce the phagocytosis time of nanomaterials by macrophages and increase the circulation time of nanomaterials in the blood
Polyvinyl alcohol (PVA) [72]Good hydrophilicity, biocompatibility, superior film, and gel-forming abilityImprove the stability of the colloidal solution
Polyacrylic acid [73]Good water solubilityImprove the biocompatibility of nanomaterials and help nanomaterials adhering

Surfactant [74]Oleic acid, lauric acid, Dodecylphosphoric acid, cetylphosphonic acid, hexadecylphosphonic acid, alkanesulfonic acid, various phosphates, etc.With good biocompatibility, it is safe and nontoxic. Although soluble in water, it can be soluble in various organic solvents.Improve the stability and biocompatibility of nanomaterials

Inorganic coatingSilica [75]Good biocompatibility, safe and nontoxic, chemically stableThe nanomaterials are prevented from degrading and coagulating in the organism, making it easier to connect functional groups
Gold [76]Biocompatibility, optical, and magnetic properties for biological applicationsImprove the stability of magnetic nanoparticles and maintain the magnetic moment of magnetic nanomaterials
Carbon [77]Stable chemical properties, good thermal stability, and good biocompatibilityImprove the stability of magnetic nanomaterials, improve the oxidation resistance and acid resistance of magnetic nanoparticles