miR-622 Induces Breast Cancer Cell MCF-7 Proliferation, Migration, and Invasion by Directly Negatively Targeting EYA1

Figure 1

Expression levels of miR-622 and EYA1 in MCF-10A, BT474, MDA-MB-231, and MCF-7 cell lines. (a) The expression of miR-622 was increased in three breast cancer cell lines (BT474, MDA-MB-231, and MCF-7) compared to breast normal epithelial cell line MCF-10A, detected by using qRT-PCR. The expression level was the highest in MCF-7 (BT474 vs. MCF-10A, ; MDA-MB-231 vs. MCF-10A, ; MCF-7 vs. MCF-10A, ). (b) The expression of EYA1 was decreased in three breast cancer cell lines (BT474, MDA-MB-231, and MCF-7) compared to breast normal epithelial cell line MCF-10A, detected by using qRT-PCR and western blot. The expression level was the lowest in MCF-7 (EYA1: BT474 vs. MCF-10A, ; MDA-MB-231 vs. MCF-10A, ; MCF-7 vs. MCF-10A, ).

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