Table of Contents Author Guidelines Submit a Manuscript
Journal of Nutrition and Metabolism
Volume 2010, Article ID 287030, 6 pages
http://dx.doi.org/10.1155/2010/287030
Research Article

Milk Products Containing Bioactive Tripeptides Have an Antihypertensive Effect in Double Transgenic Rats (dTGR) Harbouring Human Renin and Human Angiotensinogen Genes

1Institute of Biomedicine, Pharmacology, University of Helsinki, 00014 Helsinki, Finland
2Research Center, Valio Ltd, 00370 Helsinki, Finland
3Medcare Oy, 44100 Äänekoski, Finland
4Max Delbruck Center for Molecular Medicine, 13125 Berlin, Germany
5Foundation for Nutrition Research, 00039 Helsinki, Finland

Received 13 July 2009; Accepted 18 September 2009

Academic Editor: Stanley Omaye

Copyright © 2010 Tiina Jauhiainen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Y. Nakamura, N. Yamamoto, K. Sakai, and T. Takano, “Antihypertensive effect of sour milk and peptides isolated from it that are inhibitors to angiotensin I-converting enzyme,” Journal of Dairy Science, vol. 78, no. 6, pp. 1253–1257, 1995. View at Google Scholar · View at Scopus
  2. M. Sipola, P. Finckenberg, J. Santisteban, R. Korpela, H. Vapaatalo, and M.-L. Nurminen, “Long-term intake of milk peptides attenuates development of hypertension in spontaneously hypertensive rats,” Journal of Physiology and Pharmacology, vol. 52, no. 4, pp. 745–754, 2001. View at Google Scholar · View at Scopus
  3. M. Sipola, P. Finckenberg, R. Korpela, H. Vapaatalo, and M.-L. Nurminen, “Effect of long-term intake of milk products on blood pressure in hypertensive rats,” Journal of Dairy Research, vol. 69, no. 1, pp. 103–111, 2002. View at Publisher · View at Google Scholar · View at Scopus
  4. T. Jauhiainen, M. Collin, M. Narva et al., “Effect of long-term intake of milk peptides and minerals on blood pressure and arterial function in spontaneously hypertensive rats,” Milk Science International, vol. 60, no. 4, pp. 358–363, 2005. View at Google Scholar · View at Scopus
  5. Y. Hata, M. Yamamoto, M. Ohni, K. Nakajima, Y. Nakamura, and T. Takano, “A placebo-controlled study of the effect of sour milk on blood pressure in hypertensive subjects,” American Journal of Clinical Nutrition, vol. 64, no. 5, pp. 767–771, 1996. View at Google Scholar · View at Scopus
  6. L. Seppo, O. Kerojoki, T. Suomalainen, and R. Korpela, “The effect of a Lactobacillus helveticus LBK-16 H fermented milk on hypertension—a pilot study on humans,” Milk Science International, vol. 57, no. 3, pp. 124–127, 2002. View at Google Scholar · View at Scopus
  7. L. Seppo, T. Jauhiainen, T. Poussa, and R. Korpela, “A fermented milk high in bioactive peptides has a blood pressure-lowering effect in hypertensive subjects,” American Journal of Clinical Nutrition, vol. 77, no. 2, pp. 326–330, 2003. View at Google Scholar · View at Scopus
  8. S. Mizushima, K. Ohshige, J. Watanabe et al., “Randomized controlled trial of sour milk on blood pressure in borderline hypertensive men,” American Journal of Hypertension, vol. 17, no. 8, pp. 701–706, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. J. Tuomilehto, J. Lindström, J. Hyyrynen et al., “Effect of ingesting sour milk fermented using Lactobacillus helveticus bacteria producing tripeptides on blood pressure in subjects with mild hypertension,” Journal of Human Hypertension, vol. 18, no. 11, pp. 795–802, 2004. View at Publisher · View at Google Scholar · View at Scopus
  10. T. Jauhiainen, H. Vapaatalo, T. Poussa, S. Kyrönpalo, M. Rasmussen, and R. Korpela, “Lactobacillus helveticus fermented milk lowers blood pressure in hypertensive subjects in 24-h ambulatory blood pressure measurement,” American Journal of Hypertension, vol. 18, no. 12, pp. 1600–1605, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. R. J. FitzGerald, B. A. Murray, and D. J. Walsh, “Hypotensive peptides from milk proteins,” Journal of Nutrition, vol. 134, no. 4, pp. 980S–988S, 2004. View at Google Scholar · View at Scopus
  12. T. Jauhiainen and R. Korpela, “Milk peptides and blood pressure,” Journal of Nutrition, vol. 137, no. 3, pp. 825S–829S, 2007. View at Google Scholar · View at Scopus
  13. J.-Y. Xu, L.-Q. Qin, P.-Y. Wang, W. Li, and C. Chang, “Effect of milk tripeptides on blood pressure: a meta-analysis of randomized controlled trials,” Nutrition, vol. 24, no. 10, pp. 933–940, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. H. Korhonen, “Milk-derived bioactive peptides: from science to applications,” Journal of Functional Foods, vol. 1, no. 2, pp. 177–187, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. Nakamura, N. Yamamoto, K. Sakai, A. Okubo, S. Yamazaki, and T. Takano, “Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk,” Journal of Dairy Science, vol. 78, no. 4, pp. 777–783, 1995. View at Google Scholar · View at Scopus
  16. S. Luhtala, A. Vaajanen, O. Oksala, J. Valjakka, and H. Vapaatalo, “Activities of angiotensin-converting enzymes ACE1 and ACE2 and inhibition by bioactive peptides in porcine ocular tissues,” Journal of Ocular Pharmacology and Therapeutics, vol. 25, no. 1, pp. 23–28, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. Y. Nakamura, O. Masuda, and T. Takano, “Decrease of tissue angiotensin I-converting enzyme activity upon feeding sour milk in spontaneously hypertensive rats,” Bioscience, Biotechnology and Biochemistry, vol. 60, no. 3, pp. 488–489, 1996. View at Google Scholar · View at Scopus
  18. P. Jäkälä, T. Jauhiainen, R. Korpela, and H. Vapaatalo, “Bioactive tripeptides Ile-Pro-Pro and Val-Pro-Pro protect endothelial function in vitro in normotensive rats,” Basic & Clinical Pharmacology & Toxicology, vol. 102, pp. 51–52, 2008. View at Google Scholar
  19. J. Bohlender, A. Fukamizu, A. Lippoldt et al., “High human renin hypertension in transgenic rats,” Hypertension, vol. 29, no. 1, pp. 428–434, 1997. View at Google Scholar · View at Scopus
  20. E. Mervaala, D. N. Müller, F. Schmidt et al., “Blood pressure-independent effects in rats with human renin and angiotensinogen genes,” Hypertension, vol. 35, no. 2, pp. 587–594, 2000. View at Google Scholar · View at Scopus
  21. E. M. A. Mervaala, Z. J. Cheng, I. Tikkanen et al., “Endothelial dysfunction and xanthine oxidoreductase activity in rats with human renin and angiotensinogen genes,” Hypertension, vol. 37, no. 2, pp. 414–418, 2001. View at Google Scholar · View at Scopus
  22. E. M. A. Mervaala, D. N. Müller, J.-K. Park et al., “Monocyte infiltration and adhesion molecules in a rat model of high human renin hypertension,” Hypertension, vol. 33, no. 1, pp. 389–395, 1999. View at Google Scholar · View at Scopus
  23. O. Masuda, Y. Nakamura, and T. Takano, “Antihypertensive peptides are present in aorta after oral administration of sour milk containing these peptides to spontaneously hypertensive rats,” Journal of Nutrition, vol. 126, no. 12, pp. 3063–3068, 1996. View at Google Scholar · View at Scopus
  24. P. Kinnunen, O. Vuolteenaho, and H. Ruskoaho, “Mechanisms of atrial and brain natriuretic peptide release from rat ventricular myocardium: effect of stretching,” Endocrinology, vol. 132, no. 5, pp. 1961–1970, 1993. View at Publisher · View at Google Scholar · View at Scopus
  25. Z. J. Cheng, P. Finckenberg, M. Louhelainen et al., “Cardiovascular and renal effects of cyclooxygenase inhibition in transgenic rats harboring mouse renin-2 gene (TGR[mREN2]27),” European Journal of Pharmacology, vol. 461, no. 2-3, pp. 159–169, 2003. View at Publisher · View at Google Scholar · View at Scopus
  26. D. D. Kitts, Y. V. Yuan, T. Nagasawa, and Y. Moriyama, “Effect of casein, casein phosphopeptides and calcium intake on ileal C45a disappearance and temporal systolic blood pressure in spontaneously hypertensive rats,” British Journal of Nutrition, vol. 68, no. 3, pp. 765–781, 1992. View at Publisher · View at Google Scholar · View at Scopus
  27. M. Narva, R. Nevala, T. Poussa, and R. Korpela, “The effect of Lactobacillus helveticus fermented milk on acute changes in calcium metabolism in postmenopausal women,” European Journal of Nutrition, vol. 43, no. 2, pp. 61–68, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. D. A. McCarron, C. D. Morris, H. J. Henry, and J. L. Stanton, “Blood pressure and nutrient intake in the United States,” Science, vol. 224, no. 4656, pp. 1392–1398, 1984. View at Google Scholar · View at Scopus
  29. F. P. Cappuccio, P. Elliott, P. S. Allender, J. Pryer, D. A. Follman, and J. A. Cutler, “Epidemiologic association between dietary calcium intake and blood pressure: a meta-analysis of published data,” American Journal of Epidemiology, vol. 142, no. 9, pp. 935–945, 1995. View at Google Scholar · View at Scopus
  30. M. L. Nurminen, “Milk derived peptides and blood pressure,” Bulletin of the IDF, vol. 253, pp. 11–15, 2000. View at Google Scholar
  31. M. Tanaka, M. Tokuyasu, T. Matsui, and K. Matsumoto, “Endothelium-independent vasodilation effect of di- and tri-peptides in thoracic aorta of Sprague-Dawley rats,” Life Sciences, vol. 82, no. 15-16, pp. 869–875, 2008. View at Publisher · View at Google Scholar · View at Scopus
  32. T. Jauhiainen, K. Wuolle, H. Vapaatalo et al., “Oral absorption, tissue distribution and excretion of a radiolabelled analog of a milk-derived antihypertensive peptide, Ile-Pro-Pro, in rats,” International Dairy Journal, vol. 17, no. 10, pp. 1216–1223, 2007. View at Publisher · View at Google Scholar · View at Scopus
  33. P. C. van der Pijl, A. K. Kies, G. A. M. Ten Have, G. S. M. J. E. Duchateau, and N. E. P. Deutz, “Pharmacokinetics of proline-rich tripeptides in the pig,” Peptides, vol. 29, no. 12, pp. 2196–2202, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. T. Matsui, K. Tamaya, E. Seki, K. Osajima, K. Matsumoto, and T. Kawasaki, “Val-Tyr as a natural antihypertensive dipeptide can be absorbed into the human circulatory blood system,” Clinical and Experimental Pharmacology and Physiology, vol. 29, no. 3, pp. 204–208, 2002. View at Publisher · View at Google Scholar · View at Scopus
  35. M. Foltz, E. E. Meynen, V. Bianco, C. van Platerink, T. M. M. G. Koning, and J. Kloek, “Angiotensin converting enzyme inhibitory peptides from a lactotripeptide-enriched milk beverage are absorbed intact into the circulation,” Journal of Nutrition, vol. 137, no. 4, pp. 953–958, 2007. View at Google Scholar · View at Scopus
  36. M. Marttila, J. Puhakka, M. Luodonpää, O. Vuolteenaho, U. Ganten, and H. Ruskoaho, “Augmentation of BNP gene expression in atria by pressure overload in transgenic rats harbouring human renin and angiotensinogen genes,” Blood Pressure, vol. 8, no. 5-6, pp. 308–316, 1999. View at Google Scholar · View at Scopus