Effects of Growth Hormone and Insulin-Like Growth Factor-1 on Postoperative Muscle and Substrate Metabolism
Table 5
Muscle amino acids (mmol/kg ww muscle). Glutamine (Gln), branched chain amino acids (BCAAs), aromatic amino acids (AAAs), essential amino acids (EAAs), total sum of amio acids (Tot AAs).
D0
D3
Gln
Control
11.63 (10.46–12.87)
8.43 (8.14–9.07) **
GH
11.49 (10.27–13.07)
8.75 (6.85–11.07)*
GH-IGF-1
12.03 (10.72–12.93)
8.64 (10.99–6.57) **
BCAA
Control
0.38 (0.33–0.43)
0.55 (0.54–0.59) **
GH
0.47 (0.38–0.51)
0.51 (0.44–0.55) #
GH-IGF-1
0.36 (0.35–0.39)
0.50 (0.48–0.60) **
AAA
Control
0.13 (0.97–1.47)
0.21 (0.19–0.23) **
GH
0.15 (0.13–0.16)
0.17 (0.16–0.20)
GH-IGF-1
0.13 (0.10–0.15)
0.19 (0.17–0.20)*
EAA
Control
2.18 (2.07–2.43)
2.84 (2.53–3.12) **
GH
2.16 (1.87–2.24)
2.26 (2.03–2.68) #
GH-IGF-1
2.11 (1.85–2.57)
2.54 (2.28–2.72)
Tot AA
Control
21.26 (19.81–24.06)
18.69 (17.58–20.12)
GH
21.60 (18.77–23.62)
19.69 (14.36–21.78)
GH-IGF-1
21.84 (19.48–23.00)
19.53 (16.27–20.68)
*and **indicate a postoperative difference within the groups (P .05 and P .01) as compared to D0, and # indicates a difference between the controls and the groups given growth factors (P . 05). Values are given as median and quartiles.
