Methotrexate Increases Skeletal Muscle GLUT4 Expression and Improves Metabolic Control in Experimental Diabetes

Table 1

Nonfasting glucose and insulin serum levels in genetically diabetic female C57BL/KsJ-𝑚⁺/⁺𝐿𝑒𝑝𝑡^𝑑𝑏mice (𝑑𝑏⁺/𝑑𝑏⁺) and their normal littermates (𝑑𝑏⁺/⁺𝑚) at baseline and after 4 weeks of treatment with methotrexate (MTX) or vehicle.

		𝑑𝑏^+/^+𝑚		𝑑𝑏^+/𝑑𝑏^+
		Vehicle	MTX	Vehicle	MTX
Body weight (gr)	Baseline	26 ± 4	27 ± 4	40 ± 7	42 ± 6
	After treatment	28 ± 5	26 ± 5	43 ± 5	39 ± 5
Glucose (mg/dL)	Baseline	185 ± 9	178 ± 10	543 ± 28	521 ± 19
	After treatment	177 ± 11	155 ± 8^*	499 ± 26	293 ± 15^#
Insulin (pmol/L)	Baseline	68 ± 12	75 ± 7	165 ± 18	171 ± 14
	After treatment	64 ± 9	60 ± 6	159 ± 15	112 ± 11^#
HOMAIR (mmol/L*𝜇UI/L)	Baseline	5.18 ± 0.92	5.49 ± 0.53	36.87 ± 3.9	36.66 ± 4.2
	After treatment	4.66 ± 0.64	3.83 ± 0.52^#	32.65 ± 4.8	13.51 ± 2.2^#

Data are means ± SD. Only significant P are presented. ^*P < 0.05 versus baseline; ^#P < 0.001 versus baseline.