Does Branched-Chain Amino Acids Supplementation Modulate Skeletal Muscle Remodeling through Inflammation Modulation? Possible Mechanisms of Action

Figure 2

Possible role of glutamine as an intermediary of BCAA action on skeletal muscle inflammation. BCAA could modulate inflammatory response through glutamine synthesis. Such reaction occurs through BCAA transamination and generation of glutamate from 𝛼-KG. Glutamate is then converted to glutamine by glutamine synthetase. 𝛼-KG: alpha-ketoglutarate; 𝛼-KIC, 𝛼-ketoisocaproate; BCAA: branched-chain amino acids; GDH: glutamate dehydrogenase.