The Effect of Neonatal Leptin Antagonism in Male Rat Offspring Is Dependent upon the Interaction between Prior Maternal Nutritional Status and Post-Weaning Diet

Figure 4

Body weights in male offspring of either CON (a) or MHF (b) mothers treated with either saline or LA as neonates and fed either a chow or hf diet after weaning. Data are means ± SEM, 𝑛 = minimum 8 per group; (c) change in body weight (grams, shown as delta difference in body weight between LA and Sal-treated offspring, ΔLA-Sal) in CON and MHF offspring fed either a control chow or hf diet from weaning until postnatal day 110. Data are means ± SEM, 𝑛 = minimum 8 per group. Maternal diet × LA treatment interaction 𝑃<0.005; (d) fat mass (g) as quantified by DEXA scanning in offspring of CON of MHF dams, treated with either Sal or LA as neonates and fed either a control chow or hf diet after weaning. Data are means ± SEM, minimum of 8 per group. *𝑃<0.05.

(a)

(b)

(c)

(d)