The Effect of Neonatal Leptin Antagonism in Male Rat Offspring Is Dependent upon the Interaction between Prior Maternal Nutritional Status and Post-Weaning Diet

Table 2

Fasting plasma leptin, insulin, glucose, and 𝛽-hydroxybutyrate (BHB) measurements and rectal temperature in CON and MHF offspring treated with either saline (S) or pegylated leptin antagonist (LA) as neonates and fed either a chow or hf diet after weaning. Data are means ± SEM, 𝑛=8–16 per group, no significant statistical interactions.

	Leptin (ng/mL)	Insulin (ng/mL)	Glucose; (mmol/L)	BHB (mmol/L)	Rectal Temperature (°C)
CON-S-chow	10.4 ± 0.8	2.9 ± 0.2	5.98 ± 0.26	1.07 ± 0.07	37.19 ± 0.18
CON-S-hf	34.1 ± 3.6	4.6 ± 0.4	6.06 ± 0.32	1.57 ± 0.14	37.14 ± 0.13
CON-LA-chow	11.2 ± 1.4	3.4 ± 0.6	6.07 ± 0.37	1.24 ± 0.14	36.63 ± 0.19
CON-LA-hf	24.4 ± 3.9	5.9 ± 0.7	5.91 ± 0.27	1.29 ± 0.16	37.08 ± 0.14
MHF-S-chow	20.9 ± 2.9	4.4 ± 0.9	5.96 ± 0.26	0.92 ± 0.08	37.32 ± 0.15
MHF-S-hf	36.1 ± 3.0	6.1 ± 0.7	5.82 ± 0.32	1.47 ± 0.10	37.63 ± 0.21
MHF-LA-chow	16.7 ± 2.8	4.0 ± 0.6	5.28 ± 0.34	1.05 ± 0.14	37.08 ± 0.19
MHF-LA-hf	31.8 ± 4.2	6.1 ± 0.9	5.24 ± 0.31	1.61 ± 0.14	37.28 ± 0.11
Main effects
Maternal diet	𝑃<0.05	𝑃<0.05	NS	NS	𝑃<0.05
LA treatment	NS	NS	NS	NS	𝑃<0.05
PW-diet	𝑃<0.0001	𝑃<0.0001	NS	𝑃<0.0001	NS