Microarray Analyses of Genes Differentially Expressed by Diet (Black Beans and Soy Flour) during Azoxymethane-Induced Colon Carcinogenesis in Rats

Table 4

Genes significantly affected both by carcinogen (AOM) and dietary treatment in the distal colonic epithelium of male F344 rats¹.

Gene symbol	Gene title	Saline-treated			AOM-treated
		AIN	BB	SF	AIN	BB	SF
Pla2g2a	phospholipase A2, group IIA	1.0	0.64	0.33	2.5	0.97	1.2
RatNP-3	NP defensin 3	1.0	0.44	0.70	1.7	0.78	1.0
Col1a1	collagen, type I, alpha 1	1.0	0.67	0.59	2.3	0.94	0.97
Fn1	fibronectin 1	1.0	0.72	0.77	2.0	1.2	1.0
Sstr2	somatostatin receptor 2	1.0	1.4	1.7	0.69	1.1	1.2

¹Data expressed as mean fold-change differences standardized to the AIN (saline-injected) group (𝑛=4/group). There were significant main effects for injection type (saline versus AOM) and dietary treatment (AIN versus BB or SF) for each gene listed (𝑃<0.05).