The Effects of Prenatal Protein Restriction on β-Adrenergic Signalling of the Adult Rat Heart during Ischaemia Reperfusion

Table 1

Effect of maternal protein restriction on the cardiac recovery of male and female rat hearts during ischemia reperfusion. Measures of cardiac function include left ventricular pressure (LVP), the left ventricular first derivative (𝑑𝑃/𝑑𝑡_max), and heart rate (HR). These parameters were determined at baseline and during 60 min reperfusion following 30 min ischemia. Data are displayed as mean ± SEM values. Recovery 1 and 2 denote 0–30 and 31–60 min reperfusion periods, respectively.

	Males					Females
	CON		MLP		𝑃-value	CON		MLP		𝑃 value
	Mean	SE	Mean	SE		Mean	SE	Mean	SE
LVP (mmHg)
Baseline	44.67	3.0	50.18	5.3	0.38	43.74	4.1	50.57	5.1	0.31
Recovery 1	5.81	1.0	11.71	1.6	0.01	10.83	2.0	10.83	2.3	1.00
Recovery 2	7.25	1.7	15.33	3.3	0.04	11.31	2.3	13.24	2.6	0.58
Recovery 1 (% baseline)	13.8	3.3	23.31	4.0	0.09	28.41	6.3	25.16	6.6	0.88
Recovery 2 (% baseline)	18.3	5.3	33.24	8.0	0.16	29.33	6.6	31.11	7.2	0.87
HR (beats per min)
Baseline	302.42	21.3	290.9	7.0	0.61	331.76	18.8	298.23	19.7	0.23
Recovery 1	112.16	26.5	105	24.4	0.85	129.53	25.1	183.46	26.9	0.16
Recovery 2	195.42	19.3	169.54	28.2	0.47	179.41	31.5	255.36	38.0	0.14
Recovery 1 (% baseline)	30.6	7.1	43.26	6.9	0.50	37.89	7.9	60.22	8.8	0.08
Recovery 2 (% baseline)	65.1	7.1	59.45	9.8	0.66	53.65	10.9	85.03	12.2	0.07
dP/dt (mmHg/s)
Baseline	1186.01	101.9	1398.09	135.5	0.23	1252.42	106.5	1402.94	133.8	0.39
Recovery 1	381.59	32.9	625.55	78.1	0.01	515.82	66.5	530.37	53.4	0.87
Recovery 2	409.39	52.1	599.45	79.1	0.06	570.02	84.2	544.59	51.1	0.81
Recovery 1 (% baseline)	31.52	4.1	47.34	7.2	0.08	42.29	5.4	40.35	5.2	0.54
Recovery 2 (% baseline)	35.43	4.7	43.76	6.8	0.33	45.51	5.4	42.78	5.0	0.33