Neonatal SSRI Exposure Programs a Hypermetabolic State in Adult Mice

Table 1

From postnatal day 1 to 14, mice received injections of saline (control) or the SSRI sertraline. After obtaining adult phenotypes, tissue weights were obtained from 11- to 12-month-old female and 6- to 9-month-old male mice. *𝑃<0.05 versus control by Student’s 𝑡-test

		Female	Female	Male	Male
		Control	SSRI	Control	SSRI
𝑁		15	14	8	10
Body Weight	(g)	35.3 ± 1.6	29.6 ± 1.7 *	39.7 ± 2.1	35.0 ± 1.0*
Brain	(mg)	457 ± 4	458 ± 4	421 ± 12	406 ± 8
	(mg/g)	13.3 ± 0.6	16.1 ± 0.9 *	10.9 ± 0.7	11.3 ± 0.4
Liver	(mg)	1251 ± 103	1241 ± 70
	(mg/g)	37 ± 3	42 ± 2
White adipose	(mg)	2688 ± 308	1761 ± 396
	(mg/g)	73 ± 6	53 ± 9
Brown adipose	(mg)	127 ± 12	109 ± 12
	(mg/g)	3.6 ± 0.3	3.6 ± 0.3