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Journal of Nutrition and Metabolism
Volume 2012 (2012), Article ID 918571, 7 pages
Clinical Study

Meal Replacements for Weight Loss in Type 2 Diabetes in a Community Setting

1Division of Health Sciences, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA 5000, Australia
2Nutritional Interventions, Baker IDI Heart and Diabetes Institute, North Terrace, Adelaide, SA 5000, Australia

Received 10 May 2012; Accepted 6 September 2012

Academic Editor: Christel Lamberg-Allardt

Copyright © 2012 Jennifer B. Keogh and Peter M. Clifton. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. There is limited information on the effectiveness of meal replacements (MRs) as a weight-loss strategy in an unsupervised community setting. Aim. To evaluate the use of MR compared with a diet book for 6 months. Subjects and Methods. Obese subjects ( ) with type 2 diabetes mellitus were recruited from the community in Adelaide, South Australia, and randomised to intervention or control. Subjects in the intervention were advised to consume 2 MR/day for 3 months and 1 MR/day for 3 months and follow the manufacturers’ instructions from printed material and the website. Subjects in the control arm were given a commercially available diet book. Results. Consumption of 2 MR for 3 months and 1 MR for the subsequent 3 months led to weight loss of 5.5 kg (5%) and a 0.26% decrease in HbA1c while the diet book group had a weight loss of 3 kg (3%) ( for difference between groups) and a decrease in HbA1c of 0.15% (between group ns) in those who completed the 6-month study. On intention-to-treat (last observation carried forward) weight loss at 6 months was 3.4 kg in MR and 1.8 kg in control ( ). Decreases in HbA1c were 0.22% and 0.12%, respectively ( ). HDL cholesterol increased by 4% in MR and decreased by 1% in control ( ). Blood pressure decreased equally in both groups. There were reductions in fasting glucose in both groups at 6 months with no changes in LDL-cholesterol or triglyceride concentrations. Conclusion. MR confers benefits in HbA1C reduction and weight loss at 6 months in those who completed the study.