Maternal Hyperglycemia Disrupts Histone 3 Lysine 36 Trimethylation of the IGF-1 Gene

Figure 4

Maternal hyperglycemia decreased H3Me3K36 along the length of the IGF-1 gene in males. (a) Female IGF-1 histone modifications in control animals expressed as a mean percent of P1 ± standard error of the mean. (b) Female IGF-1 histone modifications in OHM animals expressed as a mean percent of gender matched control values ± standard error of the mean. (c) Male IGF-1 histone modifications in control animals expressed as a mean percent of P1 ± standard error of the mean. (d) Male IGF-1 histone modifications in OHM animals expressed as a mean percent of gender matched control values ± standard error of the mean, 𝑛=4 CON female, 𝑛=3 OHM female, 𝑛=5 CON male, and 𝑛=3 OHM male. ^∗𝑃<0.05; **𝑃<0.01; ***𝑃<0.001; ****𝑃<0.0001.

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