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Journal of Nutrition and Metabolism
Volume 2015, Article ID 157520, 9 pages
http://dx.doi.org/10.1155/2015/157520
Research Article

Short-Term High Fat Intake Does Not Significantly Alter Markers of Renal Function or Inflammation in Young Male Sprague-Dawley Rats

School of Nutrition and Health Promotion, School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA

Received 3 March 2015; Revised 8 June 2015; Accepted 9 June 2015

Academic Editor: Jonathan M. Hodgson

Copyright © 2015 Catherine Crinigan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Centers for Disease Control and Prevention, National Diabetes Statistics Report: Estimates of Diabetes and Its Burden in the United States, 2014, U.S. Department of Health and Human Services, Atlanta, Ga, USA, 2014.
  2. A. T. Reutens, “Epidemiology of diabetic kidney disease,” Medical Clinics of North America, vol. 97, no. 1, pp. 1–18, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. W. F. Keane and G. Eknoyan, “Proteinuria, albuminuria, risk, assessment, detection, elimination (PARADE): a position paper of the National Kidney Foundation,” The American Journal of Kidney Diseases, vol. 33, no. 5, pp. 1004–1010, 1999. View at Publisher · View at Google Scholar · View at Scopus
  4. A. S. Levey, D. Cattran, A. Friedman et al., “Proteinuria as a surrogate outcome in CKD: report of a scientific workshop sponsored by the National Kidney Foundation and the US Food and Drug Administration,” American Journal of Kidney Diseases, vol. 54, no. 2, pp. 205–226, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. N. Deji, S. Kume, S.-I. Araki et al., “Structural and functional changes in the kidneys of high-fat diet-induced obese mice,” American Journal of Physiology: Renal Physiology, vol. 296, no. 1, pp. F118–F126, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. G. M. Reaven, “The metabolic syndrome: time to get off the merry-go-round?” Journal of Internal Medicine, vol. 269, no. 2, pp. 127–136, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. M. C. Foster, S.-J. Hwang, S. A. Porter, J. M. Massaro, U. Hoffmann, and C. S. Fox, “Fatty kidney, hypertension, and chronic kidney disease: the framingham heart study,” Hypertension, vol. 58, no. 5, pp. 784–790, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. M. E. Altunkaynak, E. Özbek, B. Z. Altunkaynak, I. Can, D. Unal, and B. Unal, “The effects of high-fat diet on the renal structure and morphometric parametric of kidneys in rats,” Journal of Anatomy, vol. 212, no. 6, pp. 845–852, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. T. M. Dwyer, H. L. Mizelle, K. Cockrell, and P. Buhner, “Renal sinus lipomatosis and body composition in hypertensive, obese rabbits,” International Journal of Obesity and Related Metabolic Disorders, vol. 19, no. 12, pp. 869–874, 1995. View at Google Scholar · View at Scopus
  10. K. Stemmer, D. Perez-Tilve, G. Ananthakrishnan et al., “High-fat-diet-induced obesity causes an inflammatory and tumor-promoting microenvironment in the rat kidney,” Disease Models & Mechanisms, vol. 5, no. 5, pp. 627–635, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. R. Buettner, K. G. Parhofer, M. Woenckhaus et al., “Defining high-fat-diet rat models: metabolic and molecular effects of different fat types,” Journal of Molecular Endocrinology, vol. 36, no. 3, pp. 485–501, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Pranprawit, F. M. Wolber, J. A. Heyes, A. L. Molan, and M. C. Kruger, “Short-term and long-term effects of excessive consumption of saturated fats and/or sucrose on metabolic variables in Sprague Dawley rats: a pilot study,” Journal of the Science of Food and Agriculture, vol. 93, no. 13, pp. 3191–3197, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. K. L. Sweazea, M. Lekic, and B. R. Walker, “Comparison of mechanisms involved in impaired vascular reactivity between high sucrose and high fat diets in rats,” Nutrition and Metabolism, vol. 7, article 48, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. K. L. Sweazea and B. R. Walker, “High fat feeding impairs endothelin-1 mediated vasoconstriction through increased iNOS-derived nitric oxide,” Hormone and Metabolic Research, vol. 43, no. 7, pp. 470–476, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. L. González Bosc, M. L. Kurnjek, A. Müller, and N. Basso, “Effect of chronic angiotensin II inhibition on the cardiovascular system of the normal rat,” The American Journal of Hypertension, vol. 13, no. 12, pp. 1301–1307, 2000. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. K. Luu, S. Lublinsky, E. Ozcivici et al., “In vivo quantification of subcutaneous and visceral adiposity by micro-computed tomography in a small animal model,” Medical Engineering & Physics, vol. 31, no. 1, pp. 34–41, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. N. Kambham, G. S. Markowitz, A. M. Valeri, J. Lin, and V. D. D'Agati, “Obesity-related glomerulopathy: an emerging epidemic,” Kidney International, vol. 59, no. 4, pp. 1498–1509, 2001. View at Publisher · View at Google Scholar · View at Scopus
  18. R. D. Adelman, I. G. Restaino, U. S. Alon, and D. L. Blowey, “Proteinuria and focal segmental glomerulosclerosis in severely obese adolescents,” The Journal of Pediatrics, vol. 138, no. 4, pp. 481–485, 2001. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Praga, E. Hernández, E. Morales et al., “Clinical features and long-term outcome of obesity-associated focal segmental glomerulosclerosis,” Nephrology Dialysis Transplantation, vol. 16, no. 9, pp. 1790–1798, 2001. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Grubb, “Diagnostic value of analysis of cystatin C and protein HC in biological fluids,” Clinical Nephrology, vol. 38, supplement 1, pp. S20–S27, 1992. View at Google Scholar · View at Scopus
  21. J. C. Sirota, J. Klawitter, and C. L. Edelstein, “Biomarkers of acute kidney injury,” Journal of Toxicology, vol. 2011, Article ID 328120, 10 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. J. S. C. Chew, M. Saleem, C. M. Florkowski, and P. M. George, “Cystatin C: a paradigm of evidence based laboratory medicine,” The Clinical Biochemist Reviews, vol. 29, no. 2, pp. 47–62, 2008. View at Google Scholar
  23. J. S. C. Chew-Harris, C. M. Florkowski, P. M. George, J. L. Elmslie, and Z. H. Endre, “The relative effects of fat versus muscle mass on cystatin C and estimates of renal function in healthy young men,” Annals of Clinical Biochemistry, vol. 50, no. 1, pp. 39–46, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. R. Hojs, S. Bevc, R. Ekart, M. Gorenjak, and L. Puklavec, “Serum cystatin C as an endogenous marker of renal function in patients with chronic kidney disease,” Renal Failure, vol. 30, no. 2, pp. 181–186, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. N. V. McNamara, R. Chen, M. R. Janu, P. Bwititi, G. Car, and M. Seibel, “Early renal failure detection by cystatin C in Type 2 diabetes mellitus: varying patterns of renal analyte expression,” Pathology, vol. 41, no. 3, pp. 269–275, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. V. R. Dharnidharka, C. Kwon, and G. Stevens, “Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis,” American Journal of Kidney Diseases, vol. 40, no. 2, pp. 221–226, 2002. View at Publisher · View at Google Scholar · View at Scopus
  27. O. Schück, V. Teplan, M. Stollová, and J. Skibová, “Estimation of glomerular filtration rate in obese patients with chronic renal impairment based on serum cystatin C levels,” Clinical Nephrology, vol. 62, no. 2, pp. 92–96, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. Y. K. Jeon, M. R. Kim, J. E. Huh et al., “Cystatin C as an early biomarker of nephropathy in patients with type 2 diabetes,” Journal of Korean Medical Science, vol. 26, no. 2, pp. 258–263, 2011. View at Publisher · View at Google Scholar · View at Scopus
  29. C. Jin, C. Hu, A. Polichnowski et al., “Effects of renal perfusion pressure on renal medullary hydrogen peroxide and nitric oxide production,” Hypertension, vol. 53, no. 6, pp. 1048–1053, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. T. Yoshioka, I. Ichikawa, and A. Fogo, “Reactive oxygen metabolites cause massive, reversible proteinuria and glomerular sieving defect without apparent ultrastructural abnormality,” Journal of the American Society of Nephrology, vol. 2, no. 4, pp. 902–912, 1991. View at Google Scholar · View at Scopus
  31. H. F. Tbahriti, D. Meknassi, R. Moussaoui et al., “Inflammatory status in chronic renal failure: the role of homocysteinemia and pro-inflammatory cytokines,” World Journal of Nephrology, vol. 2, pp. 31–37, 2013. View at Google Scholar
  32. C. Rüster and G. Wolf, “Adipokines promote chronic kidney disease,” Nephrology Dialysis Transplantation, vol. 28, no. 4, pp. 8–14, 2013. View at Publisher · View at Google Scholar · View at Scopus
  33. S. E. Borst and C. F. Conover, “High-fat diet induces increased tissue expression of TNF-α,” Life Sciences, vol. 77, no. 17, pp. 2156–2165, 2005. View at Publisher · View at Google Scholar · View at Scopus
  34. E. Ozbek, “Induction of oxidative stress in kidney,” International Journal of Nephrology, vol. 2012, Article ID 465897, 9 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  35. R. Ozay, E. Uzar, A. Aktas et al., “The role of oxidative stress and inflammatory response in high-fat diet induced peripheral neuropathy,” Journal of Chemical Neuroanatomy, vol. 55, pp. 51–57, 2014. View at Publisher · View at Google Scholar · View at Scopus
  36. C. Ruggiero, M. Ehrenshaft, E. Cleland, and K. Stadler, “High-fat diet induces an initial adaptation of mitochondrial bioenergetics in the kidney despite evident oxidative stress and mitochondrial ROS production,” American Journal of Physiology: Endocrinology and Metabolism, vol. 300, no. 6, pp. E1047–E1058, 2011. View at Publisher · View at Google Scholar · View at Scopus
  37. A.-E. Declèves, A. V. Mathew, R. Cunard, and K. Sharma, “AMPK mediates the initiation of kidney disease induced by a high-fat diet,” Journal of the American Society of Nephrology, vol. 22, no. 10, pp. 1846–1855, 2011. View at Publisher · View at Google Scholar · View at Scopus
  38. A. E. Declèves, J. J. Rychak, D. J. Smith, and K. Sharma, “Effects of high-fat diet and losartan on renal cortical blood flow using contrast ultrasound imaging,” The American Journal of Physiology—Renal Physiology, vol. 305, no. 9, pp. F1343–F1351, 2013. View at Publisher · View at Google Scholar · View at Scopus
  39. A. H. Stark, B. Timar, and Z. Madar, “Adaptation of Sprague Dawley rats to long-term feeding of high fat or high fructose diets,” European Journal of Nutrition, vol. 39, no. 5, pp. 229–234, 2000. View at Publisher · View at Google Scholar · View at Scopus
  40. E. N. Obineche, E. Mensah-Brown, S. I. Chandranath, I. Ahmed, O. Naseer, and A. Adem, “Morphological changes in the rat kidney following long-term diabetes,” Archives of Physiology and Biochemistry, vol. 109, no. 3, pp. 241–245, 2001. View at Publisher · View at Google Scholar · View at Scopus
  41. T. Thethi, M. Kamiyama, and H. Kobori, “The link between the renin-angiotensin-aldosterone system and renal injury in obesity and the metabolic syndrome,” Current Hypertension Reports, vol. 14, no. 2, pp. 160–169, 2012. View at Publisher · View at Google Scholar · View at Scopus
  42. S. S. Waikar, V. S. Sabbisetti, and J. V. Bonventre, “Normalization of urinary biomarkers to creatinine during changes in glomerular filtration rate,” Kidney International, vol. 78, no. 5, pp. 486–494, 2010. View at Publisher · View at Google Scholar · View at Scopus
  43. G. S. Hotamisligil, N. S. Shargill, and B. M. Spiegelman, “Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance,” Science, vol. 259, no. 5091, pp. 87–91, 1993. View at Publisher · View at Google Scholar · View at Scopus
  44. P. Muntner, D. Mann, J. Winston, S. Bansilal, and M. E. Farkouh, “Serum cystatin C and increased coronary heart disease prevalence in US adults without chronic kidney disease,” The American Journal of Cardiology, vol. 102, no. 1, pp. 54–57, 2008. View at Publisher · View at Google Scholar · View at Scopus
  45. W. P. Cawthorn and J. K. Sethi, “TNF-α and adipocyte biology,” FEBS Letters, vol. 582, no. 1, pp. 117–131, 2008. View at Publisher · View at Google Scholar · View at Scopus
  46. S. A. Jones, D. J. Fraser, C. A. Fielding, and G. W. Jones, “Interleukin-6 in renal disease and therapy,” Nephrology Dialysis Transplantation, vol. 30, no. 4, pp. 564–574, 2015. View at Publisher · View at Google Scholar
  47. S. Fenkci, S. Rota, N. Sabir, Y. Sermez, A. Guclu, and B. Akdag, “Relationship of serum interleukin-6 and tumor necrosis factor alpha levels with abdominal fat distribution evaluated by ultrasonography in overweight or obese postmenopausal women,” Journal of Investigative Medicine, vol. 54, no. 8, pp. 455–460, 2006. View at Publisher · View at Google Scholar · View at Scopus
  48. P. A. Kern, S. Ranganathan, C. Li, L. Wood, and G. Ranganathan, “Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance,” American Journal of Physiology—Endocrinology and Metabolism, vol. 280, no. 5, pp. E745–E751, 2001. View at Google Scholar · View at Scopus
  49. Y. Kaya, A. Çeb, N. Söylemez, H. Dem, H. H. Alp, and E. Bakan, “Correlations between oxidative DNA damage, oxidative stress and coenzyme Q10 in patients with coronary artery disease,” International Journal of Medical Sciences, vol. 9, no. 8, pp. 621–626, 2012. View at Publisher · View at Google Scholar · View at Scopus
  50. H. K. Vincent and A. G. Taylor, “Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans,” International Journal of Obesity, vol. 30, no. 3, pp. 400–418, 2006. View at Publisher · View at Google Scholar · View at Scopus
  51. M. M. Poplawski, J. W. Mastaitis, F. Isoda, F. Grosjean, F. Zheng, and C. V. Mobbs, “Reversal of diabetic nephropathy by a ketogenic diet,” PLoS ONE, vol. 6, no. 4, Article ID e18604, 2011. View at Publisher · View at Google Scholar · View at Scopus