Clinical Study
Enteral Glutamine Administration in Critically Ill Nonseptic Patients Does Not Trigger Arginine Synthesis
Table 4
Nutrition characteristics.
| | Nutrition parameter | CON
mean (SEM) | ALA-GLN
mean (SEM) | Sig. between
groups () |
| | Calorimetry | | | | | REE (kcal/24 h) | 1847 (165) | 1998 (85) | 0.429 | | TEE (kcal/24 h) | 1998 (165) | 2176 (80) | 0.350 | | VCO2 (mL/min) | 223 (17.0) | 234 (10.7) | 0.587 | | VO2 (mL/min) | 269 (24.8) | 292 (12.4) | 0.577 | | RQ | 0.84 (0.03) | 0.81 (0.016) | 0.237 | | Nutrition | | | | | Nutrison Protein Plus/Nutrison Standard/Promote | 3/5/2 (30/50/20) | 0/1/9 (0/10/90) | | | Received % of nutritional target (study period) | | | | |
Median (IQR) | 98.5 (84.3; 100) | 100 (98.8–100) | 0.136 | | Energy (kcal/d) | 1999 (165) | 2190 (88) | 0.325 | | Received energy (kcal/d) | 1844 (183) | 2129 (67) | 0.170 | | Nitrogen | | | | | (g/d) | 101.5 (7.2) | 122.7 (5.8) | 0.034 | | (g/kg/d) | 1.41 (0.08) | 1.59 (0.11) | 0.066 | | Received nitrogen | | | | | (g/d) | 93.1 (7.9) | 119.4 (5.1) | 0.014 | | (g/kg/d) | 1.30 (0.11) | 1.54 (0.02) | 0.055 | | Received glutamine | | | | | (g/d) | 10.2 (1.0) | 35.2 (0.17) | (<0.000) | | (mmol/kg/d) | 0.98 (0.09) | 3.11 (0.03) | (<0.000) | | Citrulline (g/d) | — | — | — | | Received arginine | | | | | (g/d) | 3.6 (0.32) | 3.2 (0.13) | 0.278 | | (mmol/kg/d) | 0.29 (0.08) | 0.24 (0.01) | 0.066 | | Baseline plasma glutamine (µmol/mL) | 521 (66) | 497 (37) | 0.743 | | D3 | 539 (21) | 518 (34) | 0.592 | | D4 | 525 (32) | 510 (38) | 0.755 | | Baseline plasma citrulline (µmol/mL) | 28 (4) | 32 (3) | 0.365 | | D3 | 33 (3) | 37(2) | 0.349 | | D4 | 39 (5) | 38 (3) | 0.865 | | Baseline plasma arginine (µmol/mL) | 53 (6) | 72 (8) | 0.076 | | D3 | 64 (6) | 62 (6) | 0.833 | | D4 | 68 (7) | 64 (5) | 0.645 |
|
|
