Effect of Treatment with Salsalate, Menhaden Oil, Combination of Salsalate and Menhaden Oil, or Resolvin D1 of C57Bl/6J Type 1 Diabetic Mouse on Neuropathic Endpoints
Table 3
Effects of treatments of type 1 diabetes in C57Bl6/mice on change in body weight, blood glucose, and serum lipids.
Determination
Control (18)
Diabetic group (16)
Diabetic + salsalate group (12)
Diabetic + menhaden oil group (11)
Diabetic + salsalate + menhaden oil group (14)
Diabetic + resolvin D1 group (13)
Start weight (g)
25.5 ± 0.3
25.6 ± 0.3
25.6 ± 0.4
25.0 ± 0.5
25.0 ± 0.5
26.8 ± 0.4
Final weight (g)
30.6 ± 0.9
25.6 ± 0.3
25.4 ± 0.5
27.0 ± 0.5
26.7 ± 0.3
24.7 ± 0.3
Blood glucose (mg/dL)
183.1 ± 5
491 ± 19
463 ± 19
546 ± 21
491 ± 20
480 ± 24
Serum triglycerides (mg/dL)
9.4 ± 1.0
12.4 ± 0.9
10.6 ± 0.9
8.2 ± 0.6
9.8 ± 1.1
11.5 ± 0.9
Serum free fatty acids (mmol/L)
0.47 ± 0.08
0.41 ± 0.05
0.44 ± 0.06
0.26 ± 0.04
0.32 ± 0.06
0.38 ± 0.11
Serum cholesterol (mg/dL)
20.0 ± 1.2
26.8 ± 1.4
28.6 ± 4.0
34.2 ± 3.8
32.0 ± 3.6
27.3 ± 1.1
Data are presented as the mean ± SEM. compared to control mice. Numbers in parentheses indicate the number of experimental animals.
