Omega-3 Fatty Acids: Possible Neuroprotective Mechanisms in the Model of Global Ischemia in Rats

Figure 6

3 treatments of ischemic animals (3 animals per group) reduced the immunostaining for TNF-alpha, mainly in CA1 and CA3 hippocampal subfields and in the dentate gyrus (DG). Representative photomicrographs and quantitative measurements performed with the Image J software from 3 to 5 fields. The groups are SO, untreated ischemic (ISC) and ischemic after 3 treatments (5 and 10 mg/kg, 7 days). CA1: (A) versus SO, q = ; (B) versus ISC + 3 (5), q = ; (C) versus ISC + 3 (10), q = . CA3: (A) versus SO, q = ; (B) versus ISC + ω3 (5), q = ; (C) versus ISC + ω3 (10), q = ; (D) versus SO, q = ; (E) versus ISC + ω3 (10), q = . DG: (A) versus SO, q = ; (B) versus ISC + 3 (10), q = (one-way ANOVA and Newman-Keuls test as the post hoc test).