Transient Decrease in Circulatory Testosterone and Homocysteine Precedes the Development of Metabolic Syndrome Features in Fructose-Fed Sprague Dawley Rats
Table 2
Physical parameters.
4 weeks
12 weeks
24 weeks
Control
Fructose
Control
Fructose
Control
Fructose
Final body weight (g)
242 ± 9.0
208 ± 7.0
372 ± 9.0
332 ± 13.0
430 ± 11
418 ± 10
Body weight gain (g)
169 ± 9.0
136 ± 6.4
302 ± 8.5
260 ± 11.0
360 ± 10
348 ± 9.0
Daily food intake (g)
14 ± 0.40
13 ± 0.40
16 ± 0.30
15 ± 0.40
16 ± 0.20
16 ± 0.30
Liver (g)
7 ± 0.25
8 ± 0.29
8 ± 0.31
10 ± 0.41
10 ± 0.40
12 ± 0.40
Retroperitoneal fat (g)
2 ± 0.20
1 ± 0.18
3 ± 0.30
4 ± 0.56
6 ± 0.70
6 ± 0.70
Epididymal fat (g)
3 ± 0.31
2 ± 0.3
5 ± 0.41
5 ± 0.44
7 ± 0.70
6 ± 0.70
Testis (g)
3 ± 0.14
2 ± 0.08
3 ± 0.07
3 ± 0.05
3 ± 0.08
3 ± 0.18
Kidney (g)
2 ± 0.05
2 ± 0.06
2 ± 0.18
3 ± 0.07
2.6 ± 0.08
3.1 ± 0.05
Pancreas (g)
1.8 ± 0.06
1.7 ± 0.06
1.0 ± 0.03
1.0 ± 0.07
0.4 ± 0.10
0.5 ± 0.05
2 × 3 ANOVA
Diet
Time
Diet × time
Final body weight
S
S
NS
Body weight gain
S
S
NS
Liver
S
S
NS
Kidney
S
S
S
Values are in mean ± SE of 8 animals from each group at three time points. “” indicates statistical significance () of control and fructose-fed groups at each time point analyzed by Student’s -test. Statistical significance of diet, time, and diet time on individual parameters is also analyzed by two-way ANOVA. “S” indicates “significant” (); “NS” indicates “not significant.”
