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Journal of Nutrition and Metabolism
Volume 2016, Article ID 7924052, 9 pages
http://dx.doi.org/10.1155/2016/7924052
Research Article

Increased Gustatory Response Score in Obesity and Association Levels with IL-6 and Leptin

1Laboratory of Applied Molecular Biology and Immunology, University of Tlemcen, 13000 Tlemcen, Algeria
2Stomatology and Oral Surgery Department of Tlemcen, University Medical Centre, 13000 Tlemcen, Algeria
3Laboratory of Biotoxicology, University of Sidi Bel-Abbès, 22000 Sidi Bel-Abbès, Algeria

Received 25 January 2016; Revised 8 May 2016; Accepted 17 May 2016

Academic Editor: Mohammed S. Razzaque

Copyright © 2016 Nesrine Remla et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. The aim of this study was to investigate the relationship between the circulating IL-6 and leptin levels with taste alteration in young obese patients. Methods. A retrospective case-control study was conducted in thirty obese patients and thirty age- and sex-matched healthy controls. Results. Circulating levels of IL-6 and leptin were significantly increased in obese patients than in controls. However, catalase and ORAC levels were significantly decreased in obese patients compared to controls. Additionally, obese participants had high scores for the detection of fats (gustatory response scores [GRS]; ). Moreover, IL-6 and leptin were strongly associated with GRS alteration among patients with GRS 4 (resp., OR =17.5 [95% CI, 1.56–193.32; ]; OR = 16 [95% CI, 1.69–151.11; ]). For the Mantel-Haenszel common odds ratio estimate (MH OR), IL-6 and leptin were strongly associated with obesity, in patients with either GRS 4 or GRS > 4 (resp., MH OR = 8.77 [95% CI, 2.06–37.44; ]; MH OR = 5.76 [95% CI, 1.64–20.24; ]). Conclusions. In a low grade inflammation linked to obesity, taste alteration is associated with high levels of IL-6 and leptin.