Absorption, Metabolism, and Excretion by Freely Moving Rats of 3,4-DHPEA-EDA and Related Polyphenols from Olive Fruits (Olea europaea)

Table 2

Pharmacokinetic parameters after oral administration of 3,4-DHPEA-EDA, hydroxytyrosol, and oleuropein.

Oral administration	Dose (mol)	Metabolites	AUC (M⋅min)	AUC/Dose; (M⋅min⋅kg/mol)	(M)	/Dose; (M⋅kg/mol)	(min)
3,4-DHPEA-EDA	936.51	HT	25935.0 ± 3103.1	27.7 ± 3.3	178.87 ± 45.3	0.22 ± 0.05	30
		HVA	4180.0 ± 1646.5	4.5 ± 1.8	21.5 ± 6.9	0.03 ± 0.007	60
		HVAOH	3934.5 ± 789.7	4.2 ± 0.8	22.2 ± 2.0	0.03 ± 0.002	30
		Total	34049.5 ± 5539.3	36.4 ± 5.9
Hydroxytyrosol	648.66	HT	33160 ± 5541.5	51.1 ± 8.5	394.7 ± 58.0	0.61 ± 0.089	15
		HVA	14794.1 ± 510.1	22.8 ± 0.8	150.6 ± 9.7	0.23 ± 0.015	30
		HVAOH	4604.4 ± 885.2	7.1 ± 1.4	26.6 ± 5.2	0.04 ± 0.008	60
		Total	52585 ± 6936.8	81.0 ± 10.7
Oleuropein	555.02	Ole	1015.8 ± 222.6	1.8 ± 0.4	11.9 ± 3.2	0.021 ± 0.006	5
		HVA	515.7 ± 112.4	0.9 ± 0.2	4.1 ± 1.4	0.007 ± 0.003	60
		Total	1531.5 ± 335	2.7 ± 0.6

Values of means and ± SEM are in triplicate.