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Journal of Nutrition and Metabolism
Volume 2016 (2016), Article ID 9104792, 5 pages
Research Article

A High Protein Diet Has No Harmful Effects: A One-Year Crossover Study in Resistance-Trained Males

Exercise and Sport Science Laboratory, Nova Southeastern University, Davie, FL, USA

Received 1 July 2016; Accepted 20 September 2016

Academic Editor: Michael B. Zemel

Copyright © 2016 Jose Antonio et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The purpose of this investigation was to determine the effects of a high protein diet over a one-year period. Fourteen healthy resistance-trained men completed the study (mean ± SD; age  yr; height  cm; and average years of training  yr). In a randomized crossover design, subjects consumed their habitual or normal diet for 2 months and 4 months and alternated that with a higher protein diet (>3 g/kg/d) for 2 months and 4 months. Thus, on average, each subject was on their normal diet for 6 months and a higher protein diet for 6 months. Body composition was assessed via the Bod Pod®. Each subject provided approximately 100–168 daily dietary self-reports. During the subjects’ normal eating phase, they consumed (mean ± SD)  kcals/kg/day and  g/kg/day of protein. This significantly increased () during the high protein phase to  kcals/kg/day and  g/kg/day of protein. Our investigation discovered that, in resistance-trained men that consumed a high protein diet (~2.51–3.32 g/kg/d) for one year, there were no harmful effects on measures of blood lipids as well as liver and kidney function. In addition, despite the total increase in energy intake during the high protein phase, subjects did not experience an increase in fat mass.