Review Article

Dietary Strategies and Novel Pharmaceutical Approaches Targeting Serum ApoA-I Metabolism: A Systematic Overview

Table 9

Effect of other food components or products on apoA-I concentrations.

First author, yearFood component/productStudy design and durationParticipantsIntakeEffects

Sacks et al. (1984) [130]Eggs versus no foods containing eggsRCT crossover
3 weeks
17 healthy subjects400 kcal/day(i) No differences in fasting plasma apoA-I concentrations

Luley et al. (1986) [131]Dried garlic versus controlRCT crossover
6 weeks
(i) 34 hyperlipidemic patients3 × 198 mg/day(i) Both no differences in fasting serum apoA-I concentrations

Luley et al. (1986) [131]Dried garlic versus controlRCT crossover
6 weeks
(i) 51 hyperlipidemic patients3 × 450 mg/day(i) Both no differences in fasting serum apoA-I concentrations

Hughes et al. (1994) [132]Beta-carotene versus wheat germ oil capsulesRCT parallel
30 days
59 hyperlipidemic patients
36 healthy subjects
300 mg/day(i) No differences in fasting serum apoA-I concentrations

Nanjee et al. (1996) [133]Glucosinolate free vegetable versus Brussels sproutsRCT parallel
3 weeks
10 healthy men300 g/day(i) No differences in fasting plasma apoA-I concentrations

Nanjee et al. (1996) [133]Eugenol versus placebo capsuleRCT parallel
3 weeks
10 healthy men150 mg/day(i) No differences in fasting plasma apoA-I concentrations

Neil et al. (1996) [134]Dried garlic versus placebo powderRCT parallel
6 months
115 hypercholesterolemic subjects900 mg/day(i) No differences in fasting serum apoA-I concentrations

Itoh et al. (1997) [135]Magnesium versus placebo supplementRCT parallel
4 weeks
33 healthy subjects411–548 mg/day(i) No differences in fasting serum apoA-I concentrations

Guimarães et al. (2000) [136]Eggplant versus placebo powderRCT parallel
5 weeks
38 hypercholesterolemic subjects12 g powder/day, corresponded with 100 g eggplant/day(i) No differences in fasting serum apoA-I concentrations

Oosthuizen et al. (2000) [137]Dry beans versus no beansRCT crossover
4 weeks
22 hyperlipidemic patients110 g/day(i) No differences in fasting serum apoA-I concentrations

Gammon et al. (2012) [138]Healthy diet with versus without green kiwifruitsRCT crossover
4 weeks
85 hypercholesterolemic men2 kiwifruits/day(i) No differences in fasting serum apoA-I concentrations

Mullan et al. (2016) [139]Polyphenols versus controlRCT parallel
4 weeks
20 healthy overweight or obese subjects250 ml (361 mg) polyphenols + 120 mg vitamin C(i) No differences in fasting plasma apoA-I concentrations

Ohlsson et al. (2010) [140]Sphingolipids versus placeboRCT parallel
1 day
18 healthy men40 g high fat meal
975 mg milk sphingolipids
(i) No differences in postprandial plasma apoA-I concentrations

Castilla et al. (2006) [141]Red grape juice versus no juiceRCT parallel
2 weeks
26 hemodialysis patients
12 hemodialysis control patients
15 healthy subjects
100 ml/day(i) 13.2% in fasting plasma apoA-I concentrations comparing juice with no juice consumption in hemodialysis
(ii) 63.2% in fasting plasma apoA-I concentrations comparing juice consumption in healthy subjects with no juice consumption in hemodialysis

Roza et al. (2007) [142]Citrus flavonoids with tocotrienols versus placeboRCT parallel
12 weeks
120 hypercholesterolemic subjects270 mg citrus flavonoids + 30 mg tocotrienols/day(i) 5.0% in fasting plasma apoA-I concentrations

Salehpour et al. (2012) [143]Vitamin D3 versus control supplementRCT parallel
12 weeks
77 healthy overweight or obese subjects25 mg/day(i) 9.2% in fasting serum apoA-I

Heravifard et al. (2013) [144]Vitamin D versus calcium and vitamin D versus controlRCT parallel
12 weeks
90 patients with diabetes mellitus type 2150 mg calcium versus150 mg calcium and 500 IU vitamin D versus 250 mg calcium and 500 IU vitamin D(i) 18% in fasting serum apoA-I concentrations comparing vitamin D with
(ii) 16% in fasting serum apoA-I concentrations comparing vitamin D with calcium with

Neufingerl et al. (2013) [145]Theobromine versus placeboRCT parallel
4 weeks
152 healthy subjects0, 150, 850, and 1000 mg/day(i) 7.6% in fasting serum apoA-I concentrations comparing 850 mg theobromine with

Constans et al. (2015) [146]Orange juice versus controlRCT crossover
4 weeks
25 male subjects with 2 CVD risk factors3 × daily 200 ml(i) 6.2% in fasting plasma apoA-I concentrations comparing orange juice with

Han et al. (2016) [147]Low versus high dose of grape pomace and omija fruit versus controlRCT parallel
10 weeks
76 healthy overweight or obese subjects342.5 versus 685.0 mg grape pomace/day and 57.5 versus 115.0 mg omija/day(i) 10% in fasting plasma apoA-I concentrations after the high dose compared with
(ii) No difference in fasting plasma apoA-I concentrations after the low dose compared with control

Percentages calculated from the mean values.