The Effect of Medium Chain Triglycerides on Time to Nutritional Ketosis and Symptoms of Keto-Induction in Healthy Adults: A Randomised Controlled Clinical Trial
Table 2
Standardised effects for mean differences (LCT − MCT) in mood state, BOHB, and blood glucose for days 1 to 19.
Day →
Baseline
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
∆ symptoms from baseline
Standard difference in means
−0.08
0.19
−0.27
−0.02
−0.17
0.00
0.03
−0.28
−0.24
−0.22
0.15
−0.12
−0.26
−0.36
0.23
0.09
0.79
0.67
0.86
CL 90%
±
0.86
0.99
0.66
0.70
0.67
0.83
0.77
0.74
0.72
0.66
0.70
0.76
0.75
0.74
0.89
0.83
0.65
0.70
0.66
Clinical inference
=
+
−
+
=
+
=
+
=
∆ symptoms by day
Standard difference means
0.06
−0.16
−0.03
−0.24
0.34
−0.24
0.38
−0.10
−0.26
−0.37
0.36
0.31
−0.18
−0.19
−0.15
0.60
−0.26
0.30
0.06
CL 90%
±
0.85
0.67
0.49
0.67
0.54
0.49
0.50
0.56
0.53
0.73
0.62
0.64
0.50
0.43
0.64
0.60
0.68
0.48
0.41
Clinical inference
=
+
=
+
=
+
=
=
+
=
+
=
∆ POMS from baseline
Standard difference in means
0.46
0.26
0.65
0.35
0.62
0.40
0.34
0.71
0.11
0.23
0.33
0.28
0.45
0.54
0.44
0.34
0.48
0.64
0.61
CL 90%
±
0.71
0.77
0.80
0.77
0.61
0.80
0.90
0.84
0.84
0.83
0.84
0.79
0.86
0.80
0.73
0.60
0.86
0.80
0.21
Clinical Inference
=
∆ POMS by day
0.46
−0.20
0.25
−0.17
0.27
−0.22
−0.06
0.37
−0.60
0.12
0.10
−0.06
0.17
0.09
−0.10
−0.10
0.15
0.16
−0.03
CL 90%
±
0.71
0.35
0.37
0.41
0.59
0.62
0.38
0.57
0.30
0.47
0.35
0.43
0.33
0.27
0.58
0.35
0.63
0.27
0.23
Clinical Inference
=
+
=
+
=
+
=
++
=
=
+
=
−−−
+
=
−−
BOHB
Difference in means as a factor
1.16
1.24
1.16
1.06
1.00
1.04
1.48
1.90
1.87
2.45
1.91
1.85
2.31
1.84
1.76
2.06
1.67
1.93
1.71
1.16
CL 90%
×∕÷
1.75
1.71
1.61
1.68
1.74
1.79
1.89
1.79
1.90
1.91
1.71
1.76
1.69
1.82
1.86
2.01
1.98
1.90
1.97
1.75
Nonclinical inference
=
++
+++
++
+++
++
=
Glucose
Difference in means as a factor
0.94
0.99
0.99
0.98
1.00
0.98
0.96
0.95
1.03
0.93
0.88
1.04
0.85
1.00
0.98
0.94
0.94
0.93
1.01
0.94
CL 90%
×∕÷
1.11
1.14
1.09
1.10
1.08
1.10
1.11
1.10
1.11
1.09
1.11
1.09
1.26
1.10
1.11
1.07
1.07
1.07
1.08
1.11
Nonclinical inference
+
=
++
−−
+++
=
−
++
+
Standardised effects for mean changes (LCT − MCT) in Symptom-Q and POMS-TMDS for days 1 to 19 relative to baseline measures and for day-to-day changes. Clinical inferences based on threshold chances of harm and benefit of 25% and 0.5%. Nonclinical inferences based on threshold chances of 5% for substantial magnitudes. Positive or clinically beneficial: +++, very likely; ++, likely; +, possibly; =, unclear; negative or not clinically beneficial: −, possibly; −−, likely; −−−, very likely.
