Clinical Study

Comparison of Glycomacropeptide with Phenylalanine Free-Synthetic Amino Acids in Test Meals to PKU Patients: No Significant Differences in Biomarkers, Including Plasma Phe Levels

Table 2

Content of pure CGMP (g AA/100 g p) and DM1–4 (pr. 1000 g mixture) (CGMP and free-synthetic AA). DM1: 100% CGMP: 158.46 g = the content of each AA displayed below. DM2: 100% FSAA (the total amount of AA is shown below). DM3: 119.04 g from CGMP (+AA = the additional amount of AA from FSAA). DM4: 100% FSAA.

CGMP-20AADM1: Lacprodan CGMP-20: 158.46 gDM2: FSAADM3: Lacprodan CGMP-20: 119.04 g + FSAADM4: FSAA

g AA/100 g proteinTotal amount of AA (g)
6.4Ala8.578.406.446.31
0.3Arg0.440.434.854.85
9.2Asp12.0811.839.078.89
0.08Cys0.150.150.110.11
21.1Glu26.5325.9919.9319.52
1.2Gly1.531.501.151.13
0.2His0.160.163.03.04
11.5Ile14.5014.2110.8910.67
2.5Leu3.123.0612.1112.06
6.4Lys8.468.297.377.24
2Met2.922.853.623.57
0.2Phe0.200.200.150
12.6Pro16.4516.1112.3612.10
8.5Ser10.4610.257.867.70
18.1Thr23.6223.1417.7417.38
0.04Trp0.002.442.44
0.06Tyr0.050.0510.8110.81
9.5Val11.7611.528.838.65
Citric acid powder14.401.40
Citric acid solution (50% w/w in water)11.20
Tropical twist flavour (IFF SC401962)1.751.751.751.80
Sucrose73.0073.0080.0080.00
Water755.59787.12751.95780.17
109.88Total1000.001000.001000.001000.00
DM1234
81Protein equivalent (g/100 g)12.0012.0012.0012.00
Carbohydrate (g/100 g)7.467.308.128.00
Fat (g/100 g)0.0300.020
Energy (kcal/100 g)78778180

Part of the AA content comes from CGMP and part comes from additional FSAA: Arg: 0.33 (CGMP) + 4.52 (AA) = 4.85, His 0.12 (CGMP) + 2.92 (AA) = 3.04, Leu: 2.35 (CGMP) + 9.76 (AA) = 12.11, Lys: 6.36 (CGMP) + 1.01 (AA) = 7.37, Met: 2.19 (CGMP) + 1.43 (AA) = 3.62, Trp: 0.00 (CGMP) + 2.44 (AA) = 2.44, Tyr: 0.04 (CGMP) + 10.77 (AA) = 10.81.