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Journal of Nutrition and Metabolism
Volume 2018, Article ID 7497260, 11 pages
Clinical Study

Efficacy of an Anthocyanin and Prebiotic Blend on Intestinal Environment in Obese Male and Female Subjects

1Pharmanex Research, NSE Products Inc., 75 West Center Street, Provo, UT 84601, USA
2KGK Science Inc., 255 Queens Avenue, Suite 1440, London, Ontario, Canada N6A 5R8

Correspondence should be addressed to Steven M. Wood; moc.niksun@wevets

Received 19 March 2018; Revised 6 July 2018; Accepted 1 August 2018; Published 13 September 2018

Academic Editor: Luigi Schiavo

Copyright © 2018 Shelly N. Hester et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Anthocyanins and prebiotics impact overall health and wellness, likely through modulation of the microbiota and the intestinal ecosystem. Objectives. An 8-week open-label study in male and female volunteers with uncomplicated obesity was designed to study the efficacy of an anthocyanin and prebiotic blend in modulating intestinal microbiota and intestinal inflammation. Results. After 8 weeks of daily supplementation, participants had a significant decrease in Firmicutes () and Actinobacteria () and a significant increase in Bacteroidetes (). Bowel habits were improved as evidenced by reductions in the severity of bloating (), gas (), and abdominal pain () as well as significant improvements in stool consistency (). Finally, a nonsignificant decrease in the inflammatory marker fecal calprotectin was seen (). The supplement was safe and well tolerated. Conclusions. The results suggest that regular consumption of the anthocyanin-prebiotic blend positively modulated the intestinal ecosystem and provided insights into the mechanisms of action and its impact on health benefits.